Secretome Injection for Joint Pain

Joint pain that comes with age is often considered a regular part of aging. However, for people with osteoarthritis, the pain can be bothersome and limit their daily activities. Now, advances in medical science present new hope—secretome injection therapy, a non-surgical approach that promises to repair joint tissue from within, without surgery and long-term side effects.
Osteoarthritis (OA) is a degenerative joint disease characterized by pain, stiffness, and decreased joint function. This condition significantly affects the quality of life of sufferers.
In Indonesia, the prevalence of OA is estimated to exceed 20% in the population aged over 60 years by 2050, with a high risk of disability.
Read more: What Should You Know About Intra-Articular Injection.
Conventional and innovative therapies for OA

So far, OA treatment has been carried out using a combination of many treatments, including lifestyle changes, medication, and supportive therapy. Patients are advised to exercise regularly to maintain ideal body weight and reduce joint pressure.
In addition, drugs, such as analgesics or anti-inflammatories, aim to relieve pain and inflammation.
Meanwhile, supportive therapy, such as assistive devices or physiotherapy, helps sufferers carry out daily activities more comfortably. However, these methods are generally only symptomatic and have not been shown to stop or reverse the degeneration.
Along with the development of medical science, there is now an innovative therapy to overcome OA, known as secretome injection therapy. This therapy is used to treat OA pain and improve hair growth, skin rejuvenation, erectile dysfunction, and immune system regulation.
Secretome: regenerative therapy without surgery
What is secretome? The secretome is a collection of active substances secreted by stem cells, such as proteins, growth factors, and extracellular vesicles (e.g., exosomes). This content plays a vital role in cell communication and has excellent potential to repair and regenerate damaged tissue.
Secretome injection is a noninvasive alternative for patients with OA grades 1 and 2. This therapy can stimulate the regeneration of cartilage and soft tissue while reducing inflammation naturally without the help of chemical drugs.
In addition, secretome accelerates joint injury recovery and increases local immunity to prevent further damage to the affected area.
The National Institutes of Health (NIH) shows that secretome from mesenchymal stem cells (MSCs) can reduce OA knee pain by modulating inflammation and the activity of inflammatory mediators.
Furthermore, secretome can stimulate the production of cartilage matrix components and inhibit their degradation. This allows cartilage regeneration by stimulating the growth and proliferation of chondrocytes (cartilage cells).
Several clinical trials have shown knee OA patients experience reduced pain and increased mobility after several injections.
Compared to conventional therapy, secretome has several advantages, such as
- Works from within, rather than just on the surface.
- Stimulates the growth of healthy cells naturally.
- Medically proven anti-aging and regenerative effects
- More natural and long-lasting results
- Without living cells, it does not trigger body rejection.
The secretome injection procedure for OA

The secretome injection procedure is performed without major surgery. Patients usually receive three injections with a two-week interval between procedures. The side effects are minimal, with slight discomfort, even milder than those of hyaluronic acid injections.
When secretome is injected into the affected joint area, its bioactive content stimulates the repair of damaged tissue, especially cartilage, which is naturally difficult to repair. It also reduces chronic inflammation, the main cause of pain and swelling.
This content activates the immune system and other body cells to accelerate healing. Several clinical trials have shown that patients with chronic knee pain experience increased mobility and significant pain reduction after several secretome therapies.
Secretome's advantages over conventional therapies
- No need for surgery or hospitalization.
- Free from long-term side effects such as steroid use
- Effective for use in various age ranges
- Increasingly used in orthopedic and rehabilitation clinics
Interested in knowing if secretome therapy is right for your joint condition?
Visit GWS Medika Kalibata Clinic, a healthcare clinic in Jakarta, and consult with our medical team to find the right non-surgical solution for your joint pain.